Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of
brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

There is an emerging link between the accumulation of iron in the brain and abnormal tau
pathology in a number of neurodegenerative disorders, such as Alzheimer's disease (AD) …

The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase
that can sense environmental stimuli such as growth factors, energy state, and nutrients. It is …

Abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the
pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD) …

Peptidyl‐prolyl cis/trans isomerases (PPI ases), a unique family of molecular chaperones,
regulate protein folding at proline residues. These residues are abundant within intrinsically …

Pathology of Alzheimer's disease (AD) goes far beyond neurotoxicity resulting from
extracellular deposition of amyloid β (Aβ) plaques. Aberrant cleavage of amyloid precursor …

Background and Purpose The retention of plasma low‐density lipoprotein (LDL) particles in
subendothelial space following transcytosis across the endothelium is the initial step of …