Because of its importance for the origin of life, the nonenzymatic copying of RNA templates
has been the subject of intense study for several decades. Previous characterizations of …

While nucleoside 5′-triphosphates are precursors for RNA in modern biology, the
presumed difficulty of making these triphosphates on Hadean Earth has caused many …

Proteins, nucleic acids, lipids, and various other smaller biomolecules are united by the
presence of a common chemical entity of paramount and unique importancesthe phosphate …

Rate constants for the reaction of the title compound, 1, with a number of oxygen
nucleophiles, including structurally related phenoxides and oxygen-based α-nucleophiles …

Nonenzymatic RNA primer extension by activated mononucleotides has long served as a
model for the study of prebiotic RNA copying. We have recently shown that the rate of primer …

Previously we reported that BO-IMI, a reagent which contains a BODIPY fluorophore linked
to an imidazole group, can be used to covalently label a phosphomonoester in a single step …

To identify key parameters which influence the efficiency of nonenzymatic template-directed
oligonucleotide reactions, a kinetic study of oligoguanylate synthesis on a polycytidylate …

We report the synthesis of guanosine 5′-(4-methylimidazolyl) phosphonate (ICG), the third
member of a series of nonhydrolyzable nucleoside 5′-phosphoro-2-methylimidazolide (2 …

The phosphate group is important in biochemistry. It contributes to the structure and function
of all major classes of organic biomolecules comprising proteins, lipids, carbo-hydrates, and …

The reaction of the 5′-phosphorimidazolide of adenosine (5′-ImpA) with diadenosine
pyrophosphate (A 5′ ppA) in the presence of Na+-montmorillonite in aqueous, pH 8 …