Origins of lifetime health around the time of conception: causes and consequences

TP Fleming, AJ Watkins, MA Velazquez, JC Mathers… - The Lancet, 2018 - thelancet.com
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

[HTML][HTML] Obesity and female infertility: potential mediators of obesity's impact

DE Broughton, KH Moley - Fertility and sterility, 2017 - Elsevier
The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Placental origins of chronic disease

GJ Burton, AL Fowden… - Physiological …, 2016 - journals.physiology.org
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Intracytoplasmic sperm injection for male infertility and consequences for offspring

SC Esteves, M Roque, G Bedoschi, T Haahr… - Nature Reviews …, 2018 - nature.com
Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …

Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis

T Bamford, A Barrie, S Montgomery… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND A time lapse system (TLS) is utilized in some fertility clinics with the aim of
predicting embryo viability and chance of live birth during IVF. It has been hypothesized that …

[HTML][HTML] Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for …

MP Provost, KS Acharya, CR Acharya, JS Yeh… - Fertility and sterility, 2016 - Elsevier
Objective To examine the effect of body mass index (BMI) on IVF outcomes in fresh
autologous cycles. Design Retrospective cohort study. Setting Not applicable. Patient (s) A …

Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics

RJ Hart - Physiological reviews, 2016 - journals.physiology.org
Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial

S Einarsson, C Bergh, B Friberg, A Pinborg… - Human …, 2017 - academic.oup.com
STUDY QUESTION Does an intensive weight reduction programme prior to IVF increase live
birth rates for infertile obese women? SUMMARY ANSWER An intensive weight reduction …

Good practice recommendations for the use of time-lapse technology

ESHRE Working Group on Time-Lapse … - Human …, 2020 - academic.oup.com
SUMMARY ANSWER: The present ESHRE document provides 11 recommendations on
how to introduce TLT in the IVF laboratory. WHAT IS KNOWN ALREADY: Studies have been …

Melatonin protects against maternal obesity‐associated oxidative stress and meiotic defects in oocytes via the SIRT 3‐SOD 2‐dependent pathway

L Han, H Wang, L Li, X Li, J Ge… - Journal of pineal …, 2017 - Wiley Online Library
Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …