The population dynamics and control of tuberculosis
C Dye, BG Williams - Science, 2010 - science.org
More than 36 million patients have been successfully treated via the World Health
Organization's strategy for tuberculosis (TB) control since 1995. Despite predictions of a …
Organization's strategy for tuberculosis (TB) control since 1995. Despite predictions of a …
Innate immune gene polymorphisms in tuberculosis
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …
infectious agent. Recent studies targeting candidate genes and “case-control” association …
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …
known about the niche width of obligate human pathogens. Here we analyzed a global …
Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
JL Casanova, L Abel… - Annual review of …, 2011 - annualreviews.org
Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) have TIR intracellular
domains that engage two main signaling pathways, via the TIR-containing adaptors MyD88 …
domains that engage two main signaling pathways, via the TIR-containing adaptors MyD88 …
Human genetics of tuberculosis: a long and winding road
L Abel, J El-Baghdadi, AA Bousfiha… - … of the Royal …, 2014 - royalsocietypublishing.org
Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …
Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives
Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances …
thousands of years alongside modern human populations. Despite considerable advances …
Epidemiology and disease burden of tuberculosis in children: a global perspective
JA Seddon, D Shingadia - Infection and drug resistance, 2014 - Taylor & Francis
Our understanding of the tuberculosis (TB) epidemic in children is incomplete due to
challenges in diagnosis and reporting. Children have also been largely excluded from …
challenges in diagnosis and reporting. Children have also been largely excluded from …
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis
The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …
Pattern Recognition Receptors and Cytokines in Mycobacterium tuberculosis Infection—The Double‐Edged Sword?
MM Hossain, MN Norazmi - BioMed research international, 2013 - Wiley Online Library
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis (Mtb), remains a
major cause of human death worldwide. Innate immunity provides host defense against Mtb …
major cause of human death worldwide. Innate immunity provides host defense against Mtb …
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population
The worldwide burden of tuberculosis (TB) remains an enormous problem, and is
particularly severe in the admixed South African Coloured (SAC) population residing in the …
particularly severe in the admixed South African Coloured (SAC) population residing in the …