Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Identifying individuals with hereditary syndromes allows for timely cancer surveillance,
opportunities for risk reduction, and syndrome-specific management. Establishing criteria for …

Crohn disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD)
characterized by recurrent episodes of mucosal inflammation. This chronic mucosal …

Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) are rare
inherited polyposis syndromes with a high colorectal cancer (CRC) risk. Therefore, frequent …

We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

Background The only established treatment for preventing colorectal cancer in patients with
familial adenomatous polyposis (FAP) is colectomy, which greatly reduces patient quality of …