The gasdermins are a family of recently identified pore-forming effector proteins that cause
membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death …

Today, environmental contamination is a big concern for both developing and developed
countries. The primary sources of contamination of land, water, and air are extensive …

Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage
by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal p30 fragment that induces …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of
the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) …

Abstract Gasdermin‐D (GSDMD), a member of the gasdermin protein family, mediates
pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the
mucosal surfaces of the host nasopharynx and upper airway. Through a combination of …