The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in
excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic …

AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory
neurotransmission in the mammalian central nervous system. Modulation of AMPAR …

Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is
the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin …

The actin-related protein complex 2/3 (Arp2/3) generates branched actin networks important
for many cellular processes such as motility, vesicular trafficking, cytokinesis, and …

Vertebrate organisms adapt to a continuously changing environment by regulating the
strength of synaptic connections between brain cells. Excitatory synapses are believed to …

Cocaine is a powerful psychostimulant that is one of the most widely used illicit addictive.
The dopamine transporter (DAT) plays a major role in mediating cocaine's reward effect …

Protein interacting with C Kinase 1 (PICK1), a PDZ domain-containing scaffolding protein,
interacts with multiple different proteins in the mammalian nervous system and is believed to …

Overstimulation of glutamate receptors resulting in excessive intracellular calcium
concentrations is a major cause of neuronal cell death in epilepsy. The main source of …