A safety review of recently approved and emerging drugs for patients with relapsed or refractory multiple myeloma

S Midha, MA Hartley-Brown, CC Mo… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Multiple new drugs have been approved over the past 5 years for the treatment
of relapsed/refractory multiple myeloma (RRMM), and these are being increasingly widely …

Belantamab mafodotin: from clinical trials data to real-life experiences

S Morè, M Offidani, L Corvatta, MT Petrucci, F Fazio - Cancers, 2023 - mdpi.com
Simple Summary This paper deals with Belantamab mafodotin, a novel anti-BCMA antibody-
drug conjugate licensed by regulatory agencies for the treatment of anti-CD38-refractory …

Belantamab mafodotin in patients with relapsed/refractory multiple myeloma: results of the compassionate use or the expanded access program in Spain

J de la Rubia, R Alonso, ME Clavero, E Askari… - Cancers, 2023 - mdpi.com
Simple Summary Patients with multiple myeloma (MM) who become refractory to three or
more lines of therapy (RRMM patients) have few valid therapeutic alternatives. Among them …

Real-world effectiveness and safety of Belantamab Mafodotin monotherapy in triple-class refractory multiple myeloma

I Ntanasis-Stathopoulos, P Malandrakis… - International Journal of …, 2023 - mdpi.com
B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma
(MM). The aim of this study was to assess the effectiveness and tolerability of monotherapy …

Single‐agent belantamab mafodotin in patients with relapsed/refractory multiple myeloma: Final analysis of the DREAMM‐2 trial

AK Nooka, AD Cohen, HC Lee, A Badros… - Cancer, 2023 - Wiley Online Library
Background Patients with relapsed/refractory multiple myeloma (RRMM) have a high unmet
treatment need. Belantamab mafodotin (belamaf), a first‐in‐class, B‐cell maturation antigen …

[HTML][HTML] Recommendations for management of secondary antibody deficiency in multiple myeloma

S Giralt, S Jolles, T Kerre, HM Lazarus… - … Myeloma and Leukemia, 2023 - Elsevier
Secondary antibody deficiency (SAD) is a subtype of secondary immunodeficiency
characterized by low serum antibody concentrations (hypogammaglobulinemia) or poor …

Safety of subcutaneous daratumumab in anti-CD38 monoclonal antibody-naive patients with plasma cell disorders: a multicenter real-life experience

D De Novellis, R Fontana, S Palmieri, R Della Pepa… - Targeted Oncology, 2023 - Springer
Background Daratumumab, an anti-CD38 monoclonal antibody, is used for treatment of
multiple myeloma (MM) and light chain amyloidosis at an intravenous dosage of 16 mg/kg or …

Outcomes of Penta-Refractory Multiple Myeloma Patients Treated with or without BCMA-Directed Therapy

S Atrash, A Mammadzadeh, F Peng, O Alkharabsheh… - Cancers, 2023 - mdpi.com
Simple Summary Refractoriness to the five main myeloma treatments, including
lenalidomide, pomalidomide, bortezomib, carfilzomib, and either daratumumab or …

[HTML][HTML] Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin

C Springer, J Krauter, A Trummer - Oncotarget, 2023 - ncbi.nlm.nih.gov
In myeloma patients, high levels of soluble BCMA (sBCMA) can limit the efficacy of BCMA-
directed therapies. Belantamab-mafodotin is a BCMA antibody-drug conjugate and shows …

Effectiveness and safety of belantamab mafodotin in patients with relapsed or refractory multiple myeloma in real‐world setting: The ALFA study

M Roussel, N Texier, V Nael, J Bitetti… - European Journal of …, 2024 - Wiley Online Library
Objectives The aim of this noninterventional, retrospective ALFA study was to describe
belantamab mafodotin effectiveness and safety in patients with relapsed/refractory multiple …