Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical
development, which is linked to their limited oral bioavailability and therapeutic efficacy. To …

Globally, colorectal cancer is a major health problem that ranks in third place in terms of
occurrences and second in terms of mortality worldwide. New cases increase annually, with …

Diabetes mellitus (DM) is the most prevalent cause of diabetic retinopathy (DRP). DRP has
been recognized for a long time as a microvascular disease. Many drugs were used to treat …

Colorectal cancer (CRC) is an abnormal proliferation of cells within the colon and rectum,
leading to the formation of polyps and disruption of mucosal functions. The disease …

Abstract Background B7 homology 4 (B7-H4), a potential target for cancer therapy, has been
demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer. However, B7 …

Wound healing is a significant healthcare problem that decreases the patient's quality of life.
Hence, several agents and approaches have been widely used to help accelerate wound …

The current study focuses on assessing the activity of the N-alkylated benzimidazole based
cubosomal hydrogel (cubogel) for the topical treatment of burn wounds. The study involves …

The clinical implication of clarithromycin (CLT) is compromised owing to its poor solubility
and, subsequently, bioavailability, unpalatable taste, rapid metabolism, short half-life …

Cancer remains a leading cause of mortality. Despite significant breakthroughs in
conventional therapies, treatment is still far from ideal due to high toxicity in normal tissues …

Background: Gefitinib (GEF) is a tyrosine kinase inhibitor that has proven good efficacy
against Non-small cell Lung Carcinoma (NSCLC). It has low solubility and dissolution rate …