This title allows users to effectively diagnose and treat any acute disease of the stomach,
intestines, peritoneum, liver, and abdominal wall. Its authorship includes over 20 …

Equine laminitis is a crippling condition that continues to defy repeated efforts to delineate
the precise mechanisms involved and develop effective therapeutic strategies for use in the …

Equine laminitis is a crippling condition associated with a variety of systemic diseases.
Although it is apparent that the prodromal stages of laminitis involve microvascular …

Reasons for performing study: Lipopolysaccharide (LPS) infusion reduces digital perfusion,
but the mediators responsible remain undetermined. Objectives: To identify vasoconstrictor …

Reasons for performing study Insulin leads to overexpression of endothelin‐1 (ET‐1) in the
endothelium of insulin‐resistant rodents. If this is also the case in equine laminar tissue, this …

This study investigated the effects of cortisol and insulin, hormones that affect both
glycaemic status and vascular function, on the in vitro contractility of isolated healthy equine …

Objective—To establish an ex vivo model of blood perfusion in the distal portion of isolated
equine forelimbs that closely represents the in vivo situation in the laminar tissue of the hoof …

Haemodynamic disturbances leading to ischaemia and reperfusion injury of the digit are
thought to be involved in the pathophysiology of acute equine laminitis. Identification of …

Reasons for performing study: In vitro, glucocorticoids potentiate vasoconstriction of equine
digital vessels to catecholamines and this has been implicated as a mechanism of …

Reasons for performing study: Endothelin‐1 (ET‐1) may be a key mediator in the
pathogenesis of laminitis, but endothelin‐mediated responses in the venous …