All mammalian cells display a diverse array of glycan structures that differ from those that are
found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin …

Eosinophils are leukocytes resident in mucosal tissues. During T‐helper 2 (Th2)‐type
inflammation, eosinophils are recruited from bone marrow and blood to the sites of immune …

The 500-million-year-old adaptive immune system detects foreign (“non-self”) epitopes via B
cell-derived antibodies and/or T cell receptor interactions with major histocompatibility …

Siglecs (sialic acid immunoglobulin-like lectins) are members of the immunoglobulin gene
family that contain sialoside binding N-terminal domains. They are cell surface proteins …

Virtually all cells and extracellular material are heavily decorated by various glycans, yet our
understanding of the structure and function of these moieties lags behind the understanding …

The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …

The genetic variants leading to impairment of intellectual performance are highly diverse
and are still poorly understood. ST3GAL3 encodes the Golgi enzyme β-galactoside-α2, 3 …

Background Sialic acid–binding, immunoglobulin-like lectin (Siglec) F is a glycan-binding
protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis …

Siglecs are sialic acid-binding Ig-like lectins that recognize sialoglycans via amino-terminal
V-set domains. CD33-related Siglecs (CD33rSiglecs) on innate immune cells recognize …

Lymph nodes (LNs) are a common site of metastasis in solid cancers, and cutaneous
melanomas show inherent properties of LN colonization. However, interactions between LN …