The incidence of brain metastases has markedly increased in the past 20 years owing to
progress in the treatment of malignant solid tumours, earlier diagnosis by MRI and an …

Abstract Purpose of Review Cerebral radiation necrosis (CRN) is a major dose-limiting
adverse event of radiotherapy. The incidence rate of RN varies with the radiotherapy …

Background The primary dose-limiting toxicity of stereotactic radiosurgery (SRS) is radiation
necrosis (RN), which occurs after approximately 5% to 10% of treatments. This adverse …

To investigate late toxicity among patients with newly-diagnosed brain metastases
undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or …

A combination of immune-checkpoint inhibitors and radiation therapy (RT) represents a
promising therapeutic strategy in part mediated by the abscopal effect, but clinical …

Purpose Cyclin-dependent kinase (CDK) 4/6 inhibitors are becoming increasingly utilized in
the setting of advanced, hormone receptor (HR+) positive breast cancer. Pre-clinical data …

Pre-operative stereotactic radiosurgery (pre-SRS) has been shown as a viable treatment
option for resectable brain metastases (BM). The aim of this study is to compare oncologic …

Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients.
However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often …

The remarkable advances in the systemic therapy of metastatic melanoma have now
extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in …

Importance Preoperative stereotactic radiosurgery (SRS) has been demonstrated as a
feasible alternative to postoperative SRS for resectable brain metastases (BMs) with …