Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

[HTML][HTML] Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease

Y Koronyo, D Biggs, E Barron, DS Boyer, JA Pearlman… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Noninvasive detection of Alzheimer's disease (AD) with high specificity and
sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Retinal imaging in Alzheimer's and neurodegenerative diseases

PJ Snyder, J Alber, C Alt, LJ Bain… - Alzheimer's & …, 2021 - Wiley Online Library
In the last 20 years, research focused on developing retinal imaging as a source of potential
biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased …

Melanopsin retinal ganglion cell loss in A lzheimer disease

C La Morgia, FN Ross‐Cisneros, Y Koronyo… - Annals of …, 2016 - Wiley Online Library
Objective Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian
photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We …

Tau in Alzheimer's disease: mechanisms and therapeutic strategies

Y Gao, L Tan, JT Yu, L Tan - Current Alzheimer Research, 2018 - ingentaconnect.com
Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

Association of preclinical Alzheimer disease with optical coherence tomographic angiography findings

BE O'Bryhim, RS Apte, N Kung, D Coble… - JAMA …, 2018 - jamanetwork.com
Importance Biomarker testing for asymptomatic, preclinical Alzheimer disease (AD) is
invasive and expensive. Optical coherence tomographic angiography (OCTA) is a …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …