Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Carbapenemase-producing Pseudomonas aeruginosa –an emerging challenge

FC Tenover, DP Nicolau, CM Gill - Emerging microbes & infections, 2022 - Taylor & Francis
Carbapenem-resistant Pseudomonas aeruginosa (CR-PA) is a major healthcare-associated
pathogen worldwide. In the United States, 10–30% of P. aeruginosa isolates are …

Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired β-lactamases: 2020 update

E del Barrio-Tofiño, C López-Causapé… - International journal of …, 2020 - Elsevier
Pseudomonas aeruginosa global clones associated with multidrug-resistant (MDR) and
extensively drug-resistant (XDR) phenotypes, denominated high-risk clones, are a growing …

Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance

A Biharee, A Sharma, A Kumar, V Jaitak - Fitoterapia, 2020 - Elsevier
Background Infectious diseases are the leading cause of death in 21 st century due to
antimicrobial resistance and scarcity of new molecules to undertake rising infections. There …

Drug discovery is an eternal challenge for the biomedical sciences

H Li, W Wei, H Xu - Acta Materia Medica, 2022 - scienceopen.com
Throughout history, humans have dreamed of finding a panacea for diseases and an elixir
for immortality. As alluded to in the popular Chinese legend of Shennong, who tasted …

Injectable and self-healing probiotics-loaded hydrogel for promoting superbacteria-infected wound healing

L Mei, D Zhang, H Shao, Y Hao, T Zhang… - … Applied Materials & …, 2022 - ACS Publications
Superbacteria-induced skin wound infections are huge health challenges, resulting in
significant financial and medical costs due to notable morbidity and mortality worldwide …

[HTML][HTML] Clinical data from studies involving novel antibiotics to treat multidrug-resistant Gram-negative bacterial infections

SS Kanj, M Bassetti, P Kiratisin, C Rodrigues… - International journal of …, 2022 - Elsevier
Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

KA Glen, IL Lamont - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Polymer gels: Classification and recent developments in biomedical applications

M Chelu, AM Musuc - Gels, 2023 - mdpi.com
Polymer gels are a valuable class of polymeric materials that have recently attracted
significant interest due to the exceptional properties such as versatility, soft-structure …