Simple Summary Intersphincteric resection (ISR) is the ultimate anus-preserving surgical
technique for very low-lying rectal cancers. The oncological safety of ISR has been …

Background. Intersphincteric resection (ISR) has been a preferable alternative to
abdominoperineal resection (APR) for anal preservation in patients with low rectal cancer …

Despite the description of several new prognostic markers, colorectal cancer still represents
the third most frequent cause of cancer-related death. As immunotherapy is considered a …

Background: The efficacy of intersphincteric resection (ISR) surgery for patients with lower
rectal cancer remains unclear compared to abdominoperineal resection (APR). The aim of …

Aim This study aims to investigate the association of patient age with defecation disorders
and anal function after lower rectal cancer surgery. Methods We retrospectively reviewed the …

Introduction Rectal cancer forms a significant proportion of newly diagnosed colorectal
cancer. Treatment of rectal cancer is multi-modal, but surgery remains the cornerstone of …

The management of rectal cancer recognizes surgical resection as the most important step
towards a permanent cure. Respecting the oncological principles, functional preservation …

Supplementary Table 1 Clinical characteristics of from 20 included studies. Study Country Data
period Intersphincteric resection (ISR) Abdominoperineal resection (APR) Definition of POM …