Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy
C Bailly - Chemical reviews, 2012 - ACS Publications
1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships
The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
Hepatocellular toxicity of imidazole and triazole antimycotic agents
P Haegler, L Joerin, S Krähenbühl… - Toxicological …, 2017 - academic.oup.com
Hepatotoxicity has been described for all antimycotic azoles currently marketed. A possible
mechanism involving mitochondrial dysfunction has been postulated for ketoconazole, but …
mechanism involving mitochondrial dysfunction has been postulated for ketoconazole, but …
Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation
L Iglesias-Carres, MD Hughes, CN Steele… - The Journal of …, 2021 - Elsevier
Abstract Trimethylamine-N-oxide (TMAO) has been reported as a risk factor for
atherosclerosis development, as well as for other cardiovascular disease (CVD) …
atherosclerosis development, as well as for other cardiovascular disease (CVD) …
Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour …
M Świtalska, B Filip‐Psurska… - Journal of Cellular …, 2022 - Wiley Online Library
Abstract The acridanone derivative 5‐dimethylaminopropylamino‐8‐
hydroxytriazoloacridinone (C‐1305) has been described as a potent inhibitor of cancer cell …
hydroxytriazoloacridinone (C‐1305) has been described as a potent inhibitor of cancer cell …
Integrating machine learning and multi-omics analysis to develop an asparagine metabolism immunity index for improving clinical outcome and drug sensitivity in lung …
C Li, Y Mao, J Hu, C Su, M Li, H Tan - Immunologic Research, 2024 - Springer
Lung adenocarcinoma (LUAD) is a malignancy affecting the respiratory system. Most
patients are diagnosed with advanced or metastatic lung cancer due to the fact that most of …
patients are diagnosed with advanced or metastatic lung cancer due to the fact that most of …
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under …
M Niemira, J Dastych, Z Mazerska - Biochemical Pharmacology, 2013 - Elsevier
Induction of proteins involved in drug metabolism and in drug delivery has a significant
impact on drug–drug interactions and on the final therapeutic effects. Two antitumor acridine …
impact on drug–drug interactions and on the final therapeutic effects. Two antitumor acridine …
Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3
L Iglesias-Carres, SA Chadwick-Corbin… - The Journal of …, 2023 - Elsevier
High circulating levels of trimethylamine N-oxide (TMAO) have been associated with
cardiovascular disease risk. TMAO is formed through a microbiome-host pathway utilizing …
cardiovascular disease risk. TMAO is formed through a microbiome-host pathway utilizing …
Enhanced activity of P4503A4 and UGT1A10 induced by acridinone derivatives c-1305 and c-1311 in MCF-7 and HCT116 cancer cells: Consequences for the drugs' …
M Pawłowska, A Kwaśniewska, Z Mazerska… - International Journal of …, 2020 - mdpi.com
Activity modulation of drug metabolism enzymes can change the biotransformation of
chemotherapeutics and cellular responses induced by them. As a result, drug-drug …
chemotherapeutics and cellular responses induced by them. As a result, drug-drug …