Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis
AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
The role of natural products in drug discovery and development against neglected tropical diseases
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …
more than 1 billion people annually, including 875 million children in developing …
Marine pharmacology in 2009–2011: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral …
AMS Mayer, AD Rodríguez, O Taglialatela-Scafati… - Marine drugs, 2013 - mdpi.com
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this
review, following the format used in the 1998–2008 reviews of this series. The …
review, following the format used in the 1998–2008 reviews of this series. The …
Inhibitory activity of marine sponge-derived natural products against parasitic protozoa
In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes:
furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and …
furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and …
Current approaches to discover marine antileishmanial natural products
AG Tempone, CM de Oliveira, RGS Berlinck - Planta medica, 2011 - thieme-connect.com
Leishmaniasis is a neglected infectious disease caused by kinetoplastid protozoans. An
urgent need for novel chemotherapeutics exists. The current approaches to discover new …
urgent need for novel chemotherapeutics exists. The current approaches to discover new …
In Vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease
The in vitro activity of the methanol extracts of 51 plants randomly collected from the
Kingdom of Saudi Arabia and some of their fractions (petroleum ether, chloroform, ethyl …
Kingdom of Saudi Arabia and some of their fractions (petroleum ether, chloroform, ethyl …
Active natural product scaffolds against trypanosomatid parasites: a review
PE Cockram, TK Smith - Journal of natural products, 2018 - ACS Publications
Neglected tropical diseases caused by trypanosomatid parasites are a continuing and
escalating problem, which devastate the less economically developed cultures in countries …
escalating problem, which devastate the less economically developed cultures in countries …
Trypanocidal activity of marine natural products
Marine natural products are a diverse, unique collection of compounds with immense
therapeutic potential. This has resulted in these molecules being evaluated for a number of …
therapeutic potential. This has resulted in these molecules being evaluated for a number of …
The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
AA Pimentel, P Felibertt, F Sojo, L Colman… - Cancer chemotherapy …, 2012 - Springer
Purpose In search for new drugs derived from natural products for the possible treatment of
cancer, we studied the action of agelasine B, a compound purified from a marine sponge …
cancer, we studied the action of agelasine B, a compound purified from a marine sponge …
Integrated dataset of screening hits against multiple neglected disease pathogens
New chemical entities are desperately needed that overcome the limitations of existing
drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds …
drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds …