Endotypes of chronic rhinosinusitis: relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

A Kato, AT Peters, WW Stevens, RP Schleimer… - Allergy, 2022 - Wiley Online Library
Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

Mechanisms and pathogenesis of chronic rhinosinusitis

A Kato, RP Schleimer, BS Bleier - Journal of Allergy and Clinical …, 2022 - Elsevier
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local
inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS …

Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis

G Ryu, DW Kim - Current opinion in allergy and clinical …, 2020 - journals.lww.com
There is growing evidence of the role of S. aureus in innate and adaptive immunity, which
contribute to Th2 inflammation in CRSwNP. Innate immunity, including epithelial-derived …

[PDF][PDF] Subepithelial neutrophil infiltration as a predictor of the surgical outcome of chronic rhinosinusitis with nasal polyps

DK Kim, HS Lim, KM Eun, Y Seo, JK Kim, YS Kim… - …, 2021 - researchgate.net
Background: Neutrophils present as major inflammatory cells in refractory chronic
rhinosinusitis with nasal polyps (CRSwNP), regardless of the endotype. However, their role …

Chinese society of allergy and Chinese society of otorhinolaryngology-head and neck surgery guideline for chronic rhinosinusitis

Z Liu, J Chen, L Cheng, H Li, S Liu… - Allergy, asthma & …, 2020 - synapse.koreamed.org
The current document is based on a consensus reached by a panel of experts from the
Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck …

Systematic review of protein biomarkers in adult patients with chronic rhinosinusitis

SA Gokani, A Espehana, AC Pratas… - American Journal of …, 2023 - journals.sagepub.com
Background Chronic rhinosinusitis (CRS) is a heterogeneous condition characterized by
differing inflammatory endotypes. The identification of suitable biomarkers could enable …

[HTML][HTML] Elastase-positive neutrophils are associated with refractoriness of chronic rhinosinusitis with nasal polyps in an Asian population

DK Kim, JY Kim, YE Han, JK Kim… - Allergy, asthma & …, 2020 - synapse.koreamed.org
Purpose Various immune cells, including eosinophils and neutrophils, are known to
contribute to the development of chronic rhinosinusitis with nasal polyps (CRSwNP) …

Staphylococcus aureus Infection and Persistence in Chronic Rhinosinusitis: Focus on Leukocidin ED

D Poddighe, L Vangelista - Toxins, 2020 - mdpi.com
Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease that includes a direct
involvement of bacteria that trigger inflammation and contribute to CRS pathogenesis …

Pathogenesis and treatment of chronic rhinosinusitis from the perspective of sinonasal epithelial dysfunction

Y He, Y Fu, Y Wu, T Zhu, H Li - Frontiers in Medicine, 2023 - frontiersin.org
Background Chronic rhinosinusitis (CRS) is a clinical syndrome primarily characterized by
long-term mucosal inflammation of the nasal cavity and sinuses. The pathogenesis of CRS …

Chronic rhinosinusitis with nasal polyps in older adults: clinical presentation, pathophysiology, and comorbidity

WJ Song, JH Lee, HK Won, C Bachert - Current allergy and asthma reports, 2019 - Springer
Abstract Purpose of Review Chronic rhinosinusitis and nasal polyps (CRSwNP) is a
common condition that significantly affects patients' life. This work aims to provide an up-to …