Approximately half of all colorectal cancers show p53 (TP53) gene mutations, with higher
frequencies observed in distal colon and rectal tumors and lower frequencies in proximal …

The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal
cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell …

PURPOSE: Although the benefit from adjuvant chemotherapy has been clearly established
in patients with Dukes' C colon cancer, such benefit has been questioned in patients with …

Here we show that p53 protein is physically associated with tubulin in vivo and in vitro, and
that it localizes to cellular microtubules. Treatment with vincristine or paclitaxel before DNA …

Purpose: To define the value of thymidylate synthase (TS), Ki-67, and p53 as prognostic
markers in patients with stage II and III colon carcinoma. Patients and Methods: We …

Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove
inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins …

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of
human cancers are associated with the loss of p53 functions, where p53 often accumulates …

The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-
translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We …

Colorectal cancer is a significant cause of morbidity and mortality in Western populations.
This cancer develops as a result of the pathologic transformation of normal colonic …

The choice of study population needs to be carefully considered for studies of markers of
potential prognostic importance. Many published studies include patients with all Dukes' …