Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …

Xenograft cell transplantation into immunodeficient mice has become the gold standard for
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Zebrafish (Danio rerio) is an ideal in vivo model to study a wide variety of human cancer
types. In this review, we provide a comprehensive overview of zebrafish in the cancer drug …

The success of marker-based approaches for dissecting haematopoiesis in mouse and
human is reliant on the presence of well-defined cell surface markers specific for diverse …

Pharmacology and toxicology are part of a much broader effort to understand the
relationship between chemistry and biology. While biomedicine has necessarily focused on …

As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …

The use of patient-derived primary cell cultures in cancer preclinical assays has increased in
recent years. The management of resected tumor tissue remains complex and a number of …