The standard procedure for the osteogenic differentiation of multipotent stem cells is
treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid …

The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Metastasis, the cardinal feature of malignant tumors, is an important clinical variable in
patient prognosis. To understand the basis for metastasis, we systematically selected for …

The main physiological actions of the biologically most active metabolite of vitamin D, 1α, 25-
dihydroxyvitamin D3 (1α, 25 (OH) 2D3), are calcium and phosphorus uptake and transport …

We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has …

Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …