There are various multiple comparison procedures used in confirmatory clinical studies and
exploratory research for multiplicity adjustment. Among them are the Hochberg and …

The problem of testing multiple hypotheses using a group sequential procedure often arises
in clinical trials. We review several group sequential Holm (GSHM) type procedures …

The Hochberg procedure is known to be more powerful than the Bonferroni method but the
test statistics need to satisfy certain dependence conditions. Due to the lack of validation of …

We consider multistage tests of multiple hypotheses under a flexible setting of calendar time
and information fraction, focusing on the case where there are two hypotheses under testing …

We develop a family of logarithmic time stepwise multiple test procedures, called the Quick
procedures. Comparing with existing linear time and quadratic time procedures, the Quick …

The graphical approach has been proposed as a general framework for clinical trial designs
involving multiple hypotheses, where decisions are made only based on the observed …

This article proposes some new multiplicity adjustment procedures for clinical trials with
multiple endpoints and multiple interim analyses. The proposed sequential procedures …

Group sequential designs with multiple endpoints are widely used in clinical trials and
medical research. In the literature of group sequential designs with a single primary …

The proposed trigger strategy is a general framework for a multistage statistical design with
multiple hypotheses, allowing an adaptive selection of interim analyses. The selection of …

The use of adaptive designs can be particularly useful or at times necessary when a clinical
trial in rare disorders can only enroll a small number of patients. The global regulatory …