Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …
known to date. Because their expression and mobility can lead to genomic instability …
[HTML][HTML] Understanding'non-genetic'inheritance: insights from molecular-evolutionary crosstalk
I Adrian-Kalchhauser, SE Sultan, LNS Shama… - Trends in ecology & …, 2020 - cell.com
Understanding the evolutionary and ecological roles of'non-genetic'inheritance (NGI) is
daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights …
daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights …
[HTML][HTML] Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression
H Li, S Han, Q Sun, Y Yao, S Li, C Yuan… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Abstract Introduction: Long non-coding RNAs (lncRNAs) play key roles in the development
of atherosclerosis through the inflammatory pathway. This study aimed to investigate the role …
of atherosclerosis through the inflammatory pathway. This study aimed to investigate the role …
Evolutionary history of DNA methylation related genes in chordates: new insights from multiple whole genome duplications
DNA methylation is an important epigenetic mechanism involved in many biological
processes, ie gametogenesis and embryonic development. However, increased copy …
processes, ie gametogenesis and embryonic development. However, increased copy …
Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria
K Guynes, LA Sarre, AM Carrillo-Baltodano, BE Davies… - Genome Biology, 2024 - Springer
Background DNA methylation in the form of 5-methylcytosine (5mC) is the most abundant
base modification in animals. However, 5mC levels vary widely across taxa. While …
base modification in animals. However, 5mC levels vary widely across taxa. While …
DNA methylation in the vertebrate germline: balancing memory and erasure
O Ortega-Recalde, TA Hore - Essays in biochemistry, 2019 - portlandpress.com
Cytosine methylation is a DNA modification that is critical for vertebrate development and
provides a plastic yet stable information module in addition to the DNA code. DNA …
provides a plastic yet stable information module in addition to the DNA code. DNA …
Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes
Transcriptional silencing of retrotransposons via DNA methylation is paramount for
mammalian fertility and reproductive fitness. During germ cell development, most …
mammalian fertility and reproductive fitness. During germ cell development, most …
[HTML][HTML] Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates
Abstract Programmed cell death-1 (PD-1) and its ligands, particularly PD-L1 and PD-L2, are
the most important proteins responsible for signaling T-cell inhibition and arbitrating immune …
the most important proteins responsible for signaling T-cell inhibition and arbitrating immune …
Myxosporea (Myxozoa, Cnidaria) lack DNA cytosine methylation
R Kyger, A Luzuriaga-Neira, T Layman… - Molecular Biology …, 2021 - academic.oup.com
DNA cytosine methylation is central to many biological processes, including regulation of
gene expression, cellular differentiation, and development. This DNA modification is …
gene expression, cellular differentiation, and development. This DNA modification is …
A long intergenic non-coding RNA regulates nuclear localization of DNA methyl transferase-1
DNA methyl transferase-1 or DNMT1 maintains DNA methylation in the genome and is
important for regulating gene expression in cells. Aberrant changes in DNMT1 activity and …
important for regulating gene expression in cells. Aberrant changes in DNMT1 activity and …