The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Potential biomaterials and experimental animal models for inventing new drug delivery approaches in the neurodegenerative disorder: Multiple sclerosis
The tight junction of endothelial cells in the central nervous system (CNS) has an ideal
characteristic, acting as a biological barrier that can securely regulate the movement of …
characteristic, acting as a biological barrier that can securely regulate the movement of …
A Nanoemulgel for Nose-to-Brain delivery of Quetiapine–QbD-Enabled formulation development & in-vitro characterization
Second-generation antipsychotics, quetiapine hemifumarate (QF), exhibited highly active
against negative and positive signs of psychosis. However, contemporary reports have …
against negative and positive signs of psychosis. However, contemporary reports have …
Nose-to-brain delivery of octreotide acetate in situ gel for pituitary adenoma: pharmacological and in vitro cytotoxicity studies
Octreotide acetate (OA), a potent octapeptide, is used in the treatment of pituitary adenoma.
An approach has been made in the present research to formulate an OA-loaded intranasal …
An approach has been made in the present research to formulate an OA-loaded intranasal …
[HTML][HTML] Neurodegenerative Disorders: Mechanisms of Degeneration and Therapeutic Approaches with Their Clinical Relevance
DG Gadhave, VV Sugandhi, SK Jha… - Ageing Research …, 2024 - Elsevier
Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both
medicine and public health in the upcoming years due to global demographic changes. NDs …
medicine and public health in the upcoming years due to global demographic changes. NDs …
Mucoadhesive chitosan-poly (lactic-co-glycolic acid) nanoparticles for intranasal delivery of quetiapine–Development & characterization in physiologically relevant 3D …
Quetiapine hemifumarate (QF) delivery to the CNS via conventional formulations is
challenging due to poor solubility and lower oral bioavailability (9%). Similarly, many other …
challenging due to poor solubility and lower oral bioavailability (9%). Similarly, many other …
Nose‐to‐brain delivery of nanotherapeutics: Transport mechanisms and applications
K Xu, S Duan, W Wang, Q Ouyang, F Qin… - Wiley …, 2024 - Wiley Online Library
The blood–brain barrier presents a key limitation to the administration of therapeutic
molecules for the treatment of brain disease. While drugs administered orally or …
molecules for the treatment of brain disease. While drugs administered orally or …
Synthesis of doxorubicin pro-drug nanoparticles based on poloxamer188 and studies on their in vivo bio-security and in vitro anti-tumor activities
Y Shi, X Hou, SS Yu, X Pan, M Yang, J Hu… - Iranian Polymer Journal, 2024 - Springer
The purpose of this study was to develop a novel glutathione (GSH)-responsible doxorubicin
(DOX) pro-drug (poloxamer188-SS-DOX, PSSD) nanoparticles and study on their in vitro …
(DOX) pro-drug (poloxamer188-SS-DOX, PSSD) nanoparticles and study on their in vitro …
Fabrication of Amisulpride Nanosuspension for Nose to Brain Delivery in the Potential Antipsychotic Treatment
SP Kakad, YR Bharati, SJ Kshirsagar… - Biosciences …, 2024 - biotech-asia.org
Background: This research was aimed with the development of antipsychotic drug delivery
for olfactory administration which could deliver drug to the brain. Amisulpride is a …
for olfactory administration which could deliver drug to the brain. Amisulpride is a …
Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation
D Shah, N Mahurkar, D Gadhave, R Nikhate… - Annales …, 2023 - Elsevier
Overuse of the antipyretic agent Paracetamol (PCM) is linked to hepatotoxicity, which limits
its clinical use. The goal of this investigation was to find out how well Balsamodendron …
its clinical use. The goal of this investigation was to find out how well Balsamodendron …