Chromatin architecture reorganization during neuronal cell differentiation in Drosophila genome

KT Chathoth, NR Zabet - Genome research, 2019 - genome.cshlp.org
The organization of the genome into topologically associating domains (TADs) was shown
to have a regulatory role in development and cellular function, but the mechanism involved …

Inhibition of p53 improves CRISPR/Cas-mediated precision genome editing

E Haapaniemi, S Botla, J Persson, B Schmierer… - bioRxiv, 2017 - biorxiv.org
We report here that genome editing by CRISPR/Cas9 induces a p53-mediated DNA
damage response and cell cycle arrest. Transient inhibition of p53 prevents this response …

Statistical Modeling of Genetic and Epigenetic Factors in Gene Structures and Transcriptional Enhancers

WH Majoros - 2017 - search.proquest.com
Predicting the phenotypic effects of genetic variants is a major goal in modern genetics, with
direct applicability in both the study of diseases in humans and animals, and the breeding of …