OBJECTIVE: To develop and validate an expanded obstetric comorbidity score for predicting
severe maternal morbidity that can be applied consistently across contemporary US patient …

Background Hydroxychloroquine is generally considered safe in pregnancy for the treatment
of rheumatic conditions, but studies have been too small to evaluate teratogenicity …

Importance Increasing use of second-line noninsulin antidiabetic medication (ADM) in
pregnant individuals with type 2 diabetes (T2D) may result in fetal exposure, but their …

Background Before October 2015, pregnancy cohorts assembled from US health insurance
claims have relied on medical encounters with International Classification of Diseases-ninth …

Pregnancy is a condition of broad interest across many medical and health services
research domains, but one not easily identified in healthcare claims data. Our objective was …

Background: Metformin is a first-line pharmacotherapy for type 2 diabetes, but there is
limited evidence about its safety in early pregnancy. Objective: To evaluate the teratogenicity …

A concern with the increasing use of prescription drugs during pregnancy is teratogenic risk.
This risk is undetermined for most drugs approved in the United States (US) from 2000 to …

Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy
between countries across four continents. Methods Individually linked health data in …

Importance Congenital cytomegalovirus (cCMV) has received far less clinical and public
health attention as a teratogenic infection than the Zika virus epidemic. However, cCMV may …

Importance Although antipsychotic drugs cross the placenta and animal data suggest
potential neurotoxic effects, information regarding human neurodevelopmental …