Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …

Prokaryotes, bacteria and archaea, are the most abundant cellular organisms among those
sharing the planet Earth with human beings (among others). However, numerous ecological …

Most viruses use a hollow protein shell, the capsid, to enclose the viral genome. Virus
capsids are large, symmetric oligomers made of many copies of one or a few types of protein …

Bacteriophages have been a model system to study assembly processes for over half a
century. Formation of infectious phage particles involves specific protein-protein and protein …

Viruses, the molecular nanomachines infecting hosts ranging from prokaryotes to
eukaryotes, come in different sizes, shapes, and symmetries. Questions such as what …

Virus capsid assembly is a critical step in the viral life cycle. The underlying basis of capsid
stability is key to understanding this process. Capsid subunits interact with weak individual …

Adeno-associated virus (AAV) capsid assembly requires expression of the assembly-
activating protein (AAP) together with capsid proteins VP1, VP2, and VP3. AAP is encoded …

The genomes of most virus species have overlapping genes—two or more proteins coded
for by the same nucleotide sequence. Several explanations have been proposed for the …

Assembly of virus capsids and surface proteins must be regulated to ensure that the
resulting complex is an infectious virion. In this review, we examine assembly of virus …