Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Studies performed in the last decades have highlighted the need to better understand the
contribution of the endothelium, vascular function, oxidative stress, inflammation …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Sickle cell disease is a very variable condition, with outcomes ranging from death in
childhood to living relatively symptom free into the 8 th decade. Much of this variability is …

Sickle cell disease (SCD) is a monogenic, yet highly phenotypically variable disease with
multisystem pathology. This manuscript provides an overview of many of the known …

Cerebral infarction is a common complication of sickle cell disease and may manifest as
overt stroke or cognitive impairment associated with “silent” cerebral infarction on magnetic …

Heat-shock protein B (HSPB1) has a neuroprotective effect on brain injury and is a negative
regulator of ferroptosis. Therefore, we infer that HSPB1 plays a protective role in hypoxic …

Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in
Children With Sickle Cell Disease | Stroke Science Volunteer Warning signs SearchSearch …

All patients with HbSS (SCA) share the same genetic mutation but the clinical phenotype is
variable and difficult to predict early in life. A reliable severity predictor would be invaluable …