The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Radial glial (RG) development is essential for cerebral cortex growth and organization. In
humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons …

Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few
have been tested for in vivo relevance through genetic ablation in animal models. To …

During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

In recent years, tremendous progress has been made in understanding the mechanisms
underlying the specification of projection neurons within the mammalian neocortex. New …

The cellular complexity of human brain development has been intensively investigated,
although a regional characterization of the entire human cerebral cortex based on single …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …

Pyramidal neurons of the neocortex can be subdivided into two major groups: deep-(DL)
and upper-layer (UL) neurons. Here we report that the expression of the AT-rich DNA …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …