Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

C Li, Y Pang, Y Xu, M Lu, L Tu, Q Li… - Chemical Society …, 2023 - pubs.rsc.org
Metal agents have made incredible strides in preclinical research and clinical applications in
recent years, but their short emission/absorption wavelengths continue to be a barrier to …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

A carbonic anhydrase IX (CAIX)‐anchored rhenium (I) photosensitizer evokes pyroptosis for enhanced anti‐tumor immunity

X Su, WJ Wang, Q Cao, H Zhang, B Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
An ideal cancer treatment should not only destroy primary tumors but also improve the
immunogenicity of the tumor microenvironment to achieve a satisfactory anti‐tumor immune …

Long wavelength–emissive Ru (II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Y Xu, C Li, X Ma, W Tuo, L Tu, X Li… - Proceedings of the …, 2022 - National Acad Sciences
Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer
and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are …

Latest developments in metal complexes as anticancer agents

R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

Construction of emissive ruthenium (II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Y Xu, C Li, S Lu, Z Wang, S Liu, X Yu, X Li… - Nature …, 2022 - nature.com
Although Ru (II)-based agents are expected to be promising candidates for substituting Pt-
drug, their in vivo biomedical applications are still limited by the short excitation/emission …