Numerous studies have indicated that the progression of chronic kidney disease (CKD) to
end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic …

Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Diabetic kidney disease is a major cause of renal failure that urgently necessitates a
breakthrough in disease management. Here we show using untargeted metabolomics that …

Environmental changes can induce diversity shifts within ecosystems that affect interactions
between species. Similarly, the development of kidney disease induces shifts within the …

Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

Chronic kidney disease is highly prevalent worldwide. The decline of renal function is
associated with inadequate removal of a variety of uremic toxins that exert detrimental …

Emerging evidences demonstrate the involvement of gut microbiota in the progression of
chronic kidney disease (CKD) and CKD-associated complications including cardiovascular …

Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed
uraemic (or uremic) toxins, which inflict damage to several organs, including the …

The development of sodium-glucose transporter 2 inhibitor (SGLT2i) broadens the
therapeutic strategies in treating diabetes mellitus. By inhibiting sodium and glucose …

Non-alcoholic fatty liver disease (NAFLD) is frequently associated with metabolic disorders,
being highly prevalent in obese and diabetic patients. Many concomitant factors that …