Functional brain networks in the evaluation of patients with neurodegenerative disorders

M Perovnik, T Rus, KA Schindlbeck… - Nature Reviews …, 2023 - nature.com
Network analytical tools are increasingly being applied to brain imaging maps of resting
metabolic activity (PET) or blood oxygenation-dependent signals (functional MRI) to …

A network imaging biomarker of X‐linked dystonia‐parkinsonism

M Niethammer, CC Tang, RDG Jamora… - Annals of …, 2023 - Wiley Online Library
Objective The purpose of this study was to characterize a metabolic brain network
associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed …

[HTML][HTML] Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease

JA Barbero, P Unadkat, YY Choi, D Eidelberg - Neurotherapeutics, 2023 - Elsevier
Network analysis of functional brain scans acquired with [18 F]-fluorodeoxyglucose positron
emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state …

Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder

CC Tang, Y Nakano, A Vo, N Nguyen… - Nature …, 2024 - nature.com
Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies.
Using positron emission tomography, we assessed changes in Parkinson's disease-related …

The Role of a Dopamine-Dependent Limbic–Motor Network in Sensory Motor Processing in Parkinson Disease

LG Mann, M Servant, KR Hay, AK Song… - Journal of cognitive …, 2023 - direct.mit.edu
Limbic and motor integration is enabled by a mesial temporal to motor cortex network.
Parkinson disease (PD) is characterized by a loss of dorsal striatal dopamine but relative …

Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network

T Rus, J Mlakar, L Ležaić, A Vo… - European journal of …, 2023 - Wiley Online Library
Background and purpose Although sporadic Creutzfeldt–Jakob disease (sCJD) is a rare
cause of dementia, it is critical to understand its functional networks as the prion protein …

Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses

A Vo, N Nguyen, K Fujita, KA Schindlbeck… - Cerebral …, 2023 - academic.oup.com
Primary dystonia is thought to emerge through abnormal functional relationships between
basal ganglia and cerebellar motor circuits. These interactions may differ across disease …

BCKDK rs14235 A allele is associated with milder motor impairment and altered network topology in Parkinson's disease

Z Chen, B Wu, G Li, L Zhou, L Zhang, J Liu - medRxiv, 2023 - medrxiv.org
Background A multitude of genetic variants confer a risk of Parkinson's disease (PD),
however, whether these risk variants affected the motor symptoms of PD patients remain …

[HTML][HTML] Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats

H Endepols, N Apetz, L Vieth, C Lesser… - International journal of …, 2024 - mdpi.com
Compensatory changes in brain connectivity keep motor symptoms mild in prodromal
Parkinson's disease. Studying compensation in patients is hampered by the steady …

Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia

T Rus, M Perovnik, A Vo, N Nguyen… - Human Brain …, 2023 - Wiley Online Library
Behavioral variant of frontotemporal dementia (bvFTD) is common among young‐onset
dementia patients. While bvFTD‐specific multivariate metabolic brain pattern (bFDRP) has …