DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan

T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …

[HTML][HTML] Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

S Salvioli, MS Basile, L Bencivenga, S Carrino… - Ageing Research …, 2023 - Elsevier
According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

RF Hillary, AJ Stevenson, DL McCartney… - Clinical …, 2020 - Springer
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …

Education and lifestyle factors are associated with DNA methylation clocks in older African Americans

W Zhao, F Ammous, S Ratliff, J Liu, M Yu… - International journal of …, 2019 - mdpi.com
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and are
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …

Leisure-time and occupational physical activity associates differently with epigenetic aging

A Kankaanpää, A Tolvanen, S Bollepalli… - … and Science in …, 2020 - pmc.ncbi.nlm.nih.gov
Purpose Greater leisure-time physical activity (LTPA) associates with healthier lives, but
knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA …

Association of blood chemistry quantifications of biological aging with disability and mortality in older adults

DC Parker, BN Bartlett, HJ Cohen… - The Journals of …, 2020 - academic.oup.com
Quantification of biological aging has been proposed for population surveillance of age-
related decline in system integrity and evaluation of geroprotective therapies. However …

The Danish twin registry: an updated overview

DA Pedersen, LA Larsen, M Nygaard… - Twin Research and …, 2019 - cambridge.org
The Danish Twin Registry (DTR) was established in the 1950s, when twins born from 1870
to 1910 were ascertained, and has since been extended to include twins from birth cohorts …

Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms

AS Zannas - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Psychosocial stress—especially when chronic, excessive, or occurring early in life—has
been associated with accelerated aging and increased disease risk. With rapid aging of the …

DNA methylation age as a biomarker for cancer

CHE Lau, O Robinson - International Journal of Cancer, 2021 - Wiley Online Library
Cancer is well established as an age‐associated disease, and there is substantial overlap in
the molecular, cellular and physiological changes observed with both ageing and the …

Epigenetic aging and rheumatoid arthritis

N Mukherjee, TC Harrison - The Journals of Gerontology: Series …, 2024 - academic.oup.com
This is the first known comparative assessment of the associations of epigenetic age
estimates with the prevalence of rheumatoid arthritis (RA). We used data available in Gene …