The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Blood-protein digestion is a key physiological process providing essential nutrients for ticks
and is a prerequisite for the transmission of tick-borne pathogens. Recently, substantial …

Reaction rate acceleration using green methods is an intriguing area of research for
chemists. In this regard, water as a “green solvent” plays a crucial role in the acceleration of …

Specific targeting and cellular internalization are key properties for carriers of antitumor
therapeutic agents. Here, we develop a drug carrier through the attachment of substrate of …

Abstract δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a
lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau …

Azapeptides are peptide analogs in which one or more of the amino residues is replaced by
a semicarbazide. This substitution of a nitrogen for the α-carbon center results in …

Conspectus Mimicry of bioactive conformations is critical for peptide-based medicinal
chemistry because such peptidomimetics may augment stability, enhance affinity, and …

Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni,
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …

Legumain (AEP) is a lysosomal cysteine protease that was first characterized in leguminous
seeds and later discovered in higher eukaryotes. AEP upregulation is linked to a number of …

Schistosomiasis is a parasitic disease caused by trematode worms of the genus
Schistosoma and affects over 200 million people worldwide. The control and treatment of …