Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of
mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom …

Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

A wide array of biocompatible micro/nanorobots are designed for targeted drug delivery and
precision therapy largely depending on their self-adaptive ability overcoming complex …

Cryo-sample preparation is a vital step in the process of obtaining high-resolution structures
of macromolecules by using the single-particle cryo–electron microscopy (cryo-EM) method; …

GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular
trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization …

Sodium glucose co-transporters (SGLT) harness the electrochemical gradient of sodium to
drive the uphill transport of glucose across the plasma membrane. Human SGLT1 (hSGLT1) …

Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular
monoamine transporter 2 (VMAT2) into synaptic vesicles for storage and subsequent …

Neutropenia and neutrophil dysfunction in glycogen storage disease type 1b (GSD1b) and
severe congenital neutropenia type 4 (SCN4), associated with deficiencies of the glucose-6 …

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …

Abstract Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption.
SGLT2 inhibitors suppress renal glucose reabsorption, therefore reducing blood glucose …