Mimicking the natural basement membrane for advanced tissue engineering
Advancements in the field of tissue engineering have led to the elucidation of physical and
chemical characteristics of physiological basement membranes (BM) as specialized forms of …
chemical characteristics of physiological basement membranes (BM) as specialized forms of …
3D traction force microscopy in biological gels: from single cells to multicellular spheroids
Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …
migration, and differentiation. Current understanding of cell traction force is largely derived …
Regulation of tumor invasion by the physical microenvironment: lessons from breast and brain cancer
GF Beeghly, KY Amofa, C Fischbach… - Annual review of …, 2022 - annualreviews.org
The success of anticancer therapies is often limited by heterogeneity within and between
tumors. While much attention has been devoted to understanding the intrinsic molecular …
tumors. While much attention has been devoted to understanding the intrinsic molecular …
Engineering strategies to capture the biological and biophysical tumor microenvironment in vitro
Despite decades of research and advancements in diagnostic and treatment modalities,
cancer remains a major global healthcare challenge. This is due in part to a lack of model …
cancer remains a major global healthcare challenge. This is due in part to a lack of model …
[HTML][HTML] A deep learning-based pipeline for analyzing the influences of interfacial mechanochemical microenvironments on spheroid invasion using differential …
Metastasis is the leading cause of cancer-related deaths. During this process, cancer cells
are likely to navigate discrete tissue-tissue interfaces, enabling them to infiltrate and spread …
are likely to navigate discrete tissue-tissue interfaces, enabling them to infiltrate and spread …
Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging
Quantitative characterisation of micro-scale mechanical properties of the extracellular matrix
(ECM) and dynamic cell-ECM interactions can significantly enhance fundamental …
(ECM) and dynamic cell-ECM interactions can significantly enhance fundamental …
Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues
Viscoelastic transformation of tissue drives aberrant cellular functions and is an early
biomarker of disease pathogenesis. Tissues scale a range of viscoelastic moduli, from …
biomarker of disease pathogenesis. Tissues scale a range of viscoelastic moduli, from …
Reciprocity of cell mechanics with extracellular stimuli: emerging opportunities for translational medicine
Human cells encounter dynamic mechanical cues in healthy and diseased tissues, which
regulate their molecular and biophysical phenotype, including intracellular mechanics as …
regulate their molecular and biophysical phenotype, including intracellular mechanics as …
Optical coherence tomography
Optical coherence tomography (OCT) is a non-contact method for imaging the topological
and internal microstructure of samples in three dimensions. OCT can be configured as a …
and internal microstructure of samples in three dimensions. OCT can be configured as a …
Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine
N Leartprapun, SG Adie - Biomedical Optics Express, 2022 - opg.optica.org
Optical elastography offers a rich body of imaging capabilities that can serve as a bridge
between organ-level medical elastography and single-molecule biophysics. We review the …
between organ-level medical elastography and single-molecule biophysics. We review the …