Revisiting amino acids and peptides as anti-glycation agents

H Chilukuri, MJ Kulkarni, M Fernandes - MedChemComm, 2018 - pubs.rsc.org
The importance of controlling or preventing protein glycation cannot be overstated and is of
prime importance in the treatment of diabetes and associated complications including …

Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin

G Prasanna, NT Saraswathi - International Journal of Biological …, 2017 - Elsevier
In this study, we report the protective effects of linolenic acid towards the formation of early
(HbA 1 c) and advanced glycation end-products (AGEs) based on fluorescence, circular …

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients

H Mirmiranpour, SZ Bathaie, S Khaghani… - International Journal of …, 2021 - Springer
Background Lysine treatment decreased diabetic complications associated with type 2
diabetes in the rat models of diabetes and in vitro. Aims/hypothesis Herein, in a single …

Prevention of α-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract …

F Bahmani, SZ Bathaie, SJ Aldavood… - International journal of …, 2019 - Elsevier
The principle role of α-crystallin is chaperoning activity that protect s other proteins against
different stresses. High glucose concentration induces the osmotic stress and results in …

1, 8 cineole protects type 2 diabetic rats against diabetic nephropathy via inducing the activity of glyoxalase-I and lowering the level of transforming growth factor-1β

S Mahdavifard, M Nakhjavani - Journal of Diabetes & Metabolic Disorders, 2022 - Springer
Purpose Diabetes leading to the production and circulation of glycation products along with
the reduction of the activity of glyoxalase-I (GLO-I) contribute to diabetic nephropathy …

Supplementation with cysteine improved metabolic syndrome in rats by increasing antioxidant potential in the liver and adipose tissue, as well as decreasing hepatic …

S Mahdavifard, M Nakhjavani - Food Bioscience, 2024 - Elsevier
Insulin resistance is a key characteristic of metabolic syndrome (MetS). The hepatic nuclear
factor-κB (NF-κB) signaling pathway plays a crucial role in insulin resistance and the …

[HTML][HTML] Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide …

M Nasri, S Mahdavifard, E Babaeenezhad… - Iranian journal of …, 2020 - ncbi.nlm.nih.gov
Objective (s): The present study sought to evaluate the beneficial effects of histidine (His) on
oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti …

Carbonyl scavenging and chemical chaperon like function of essential amino acids attenuates non-enzymatic glycation of albumin

S Awasthi, NT Saraswathi - RSC advances, 2016 - pubs.rsc.org
Besides being fundamental in the development of severe complications such as retinopathy,
neuropathy and kidney disorders, non-enzymatic glycation also modulates the structure and …

Aspartic acid functions as carbonyl trapper to inhibit the formation of advanced glycation end products by chemical chaperone activity

G Prasanna, NT Saraswathi - Journal of Biomolecular Structure and …, 2016 - Taylor & Francis
Advanced glycation end products (AGEs) were implicated in pathology of numerous
diseases. In this study, we present the bioactivity of aspartic acid (Asp) to inhibit the AGEs …

Detection of L-cysteine in urine samples based on CdS/TiO2-modified extended-gate field-effect transistor photoelectrochemical sensor

Y Zhang, J Yu, W Huang, Z Jin, J Li - Microchimica Acta, 2023 - Springer
A novel extended-gate field-effect transistor (FET) photoelectrochemical (EGFET PEC)
sensor was designed for highly sensitive detection of L-cysteine (L-Cys). TiO2 was initially …