Rab family of small GTPases: an updated view on their regulation and functions
The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …
Epigenetic regulation of autophagy-related genes: Implications for neurodevelopmental disorders
EI Lewerissa, N Nadif Kasri, K Linda - Autophagy, 2024 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …
important for the clearance of cytosolic contents to maintain cellular homeostasis and …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
E Kallergi, AD Daskalaki, A Kolaxi, C Camus… - Nature …, 2022 - nature.com
The pruning of dendritic spines during development requires autophagy. This process is
facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that …
facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that …
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
M Overhoff, F Tellkamp, S Hess, M Tolve, J Tutas… - The EMBO …, 2022 - embopress.org
Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …
components. However, accumulating evidence indicates that autophagy is not merely a …
[HTML][HTML] Regulation of neuronal autophagy and the implications in neurodegenerative diseases
Neurons are highly polarized and post-mitotic cells with the specific requirements of
neurotransmission accompanied by high metabolic demands that create a unique challenge …
neurotransmission accompanied by high metabolic demands that create a unique challenge …
The endolysosomal system and proteostasis: from development to degeneration
How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …
membrane transport across their elaborate cellular landscape and to maintain proteostasis …
Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology
R Diab, F Pilotto, S Saxena - Frontiers in cellular neuroscience, 2023 - frontiersin.org
The proper functioning of the cell clearance machinery is critical for neuronal health within
the central nervous system (CNS). In normal physiological conditions, the cell clearance …
the central nervous system (CNS). In normal physiological conditions, the cell clearance …
Molecular mechanism and regulation of autophagy and its potential role in epilepsy
H Zhu, W Wang, Y Li - Cells, 2022 - mdpi.com
Autophagy is an evolutionally conserved degradation mechanism for maintaining cell
homeostasis whereby cytoplasmic components are wrapped in autophagosomes and …
homeostasis whereby cytoplasmic components are wrapped in autophagosomes and …
Autophagy and the endolysosomal system in presynaptic function
The complex morphology of neurons, the specific requirements of synaptic
neurotransmission and the accompanying metabolic demands create a unique challenge for …
neurotransmission and the accompanying metabolic demands create a unique challenge for …