The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

A Nogal, AM Valdes, C Menni - Gut microbes, 2021 - Taylor & Francis
The gut microbiota plays an important role in cardio-metabolic diseases with diet being
among the strongest modulators of gut microbiota composition and function. Resistant …

Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies

L Schwingshackl, G Hoffmann, AM Lampousi… - European journal of …, 2017 - Springer
The aim of this systematic review and meta-analysis was to synthesize the knowledge about
the relation between intake of 12 major food groups and risk of type 2 diabetes (T2D). We …

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease

NM Vogt, KA Romano, BF Darst, CD Engelman… - Alzheimer's research & …, 2018 - Springer
Abstract Background Trimethylamine N-oxide (TMAO), a small molecule produced by the
metaorganismal metabolism of dietary choline, has been implicated in human disease …

Circulating levels of the short-chain fatty acid acetate mediate the effect of the gut microbiome on visceral fat

A Nogal, P Louca, X Zhang, PM Wells… - Frontiers in …, 2021 - frontiersin.org
Background Acetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has
been implicated in cardio-metabolic health. Here we examine the relationships of circulating …

Gut microbiota metabolites and risk of major adverse cardiovascular disease events and death: a systematic review and meta‐analysis of prospective studies

Y Heianza, W Ma, JAE Manson… - Journal of the American …, 2017 - Am Heart Assoc
Background Gut microbial metabolites have been implicated as novel risk factors for
cardiovascular events and premature death. The strength and consistency of associations …

Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction

S Chen, A Henderson, MC Petriello, KA Romano… - Cell metabolism, 2019 - cell.com
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …

Microbial modulation of cardiovascular disease

JM Brown, SL Hazen - Nature Reviews Microbiology, 2018 - nature.com
Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …

Precision nutrition and the microbiome, part I: current state of the science

S Mills, C Stanton, JA Lane, GJ Smith, RP Ross - Nutrients, 2019 - mdpi.com
The gut microbiota is a highly complex community which evolves and adapts to its host over
a lifetime. It has been described as a virtual organ owing to the myriad of functions it …