Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems

AZ Alkilani, J Nasereddin, R Hamed, S Nimrawi… - Pharmaceutics, 2022 - mdpi.com
The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

Advances of microneedles in biomedical applications

J Xu, D Xu, X Xuan, H He - Molecules, 2021 - mdpi.com
A microneedle (MN) is a painless and minimally invasive drug delivery device initially
developed in 1976. As microneedle technology evolves, microneedles with different shapes …

[HTML][HTML] Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management

S Demartis, QK Anjani, F Volpe-Zanutto… - International Journal of …, 2022 - Elsevier
Melanoma remains a global concern, but current therapies present critical limitations
pointing out the urgent need for novel strategies. Among these, the cutaneous delivery of …

Microneedle-mediated transdermal delivery of biopharmaceuticals

HX Nguyen, CN Nguyen - Pharmaceutics, 2023 - mdpi.com
Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …

[HTML][HTML] Liposome-loaded polymeric microneedles for enhanced skin deposition of rifampicin

QK Anjani, AK Pandya, S Demartis… - International Journal of …, 2023 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is a prevailing bacterial pathogen
linked to superficial skin and soft tissue infections (SSTIs). Rifampicin (RIF), a potent …

[HTML][HTML] Rapidly dissolving microneedles for the delivery of steroid-loaded nanoparticles intended for the treatment of inflammatory skin diseases

H Dawud, A Abu Ammar - Pharmaceutics, 2023 - mdpi.com
Drug delivery through the skin has immense advantages compared to other routes of
administration and offers an optimal way to treat inflammatory skin diseases, where …

Polymeric microneedles: an emerging paradigm for advanced biomedical applications

D Kulkarni, D Gadade, N Chapaitkar, S Shelke… - Scientia …, 2023 - mdpi.com
Microneedles are gaining popularity as a new paradigm in the area of transdermal drug
delivery for biomedical and healthcare applications. Efficient drug delivery with minimal …

Microneedle-mediated transdermal delivery of drug-carrying nanoparticles

X Jiang, H Zhao, W Li - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Drug-carrying nanoparticles have obtained great attention for disease treatments due to the
fact that they can improve drug solubility, provide drug protection and prolong release …

Exosome-loaded microneedle patches: promising factor delivery route

S Fathi-Karkan, M Heidarzadeh, MT Narmi… - International Journal of …, 2023 - Elsevier
During the past decades, the advent of different microneedle patch (MNPs) systems paves
the way for the targeted and efficient delivery of several growth factors into the injured sites …

Recent advances in microneedle designs and their applications in drug and cosmeceutical delivery

R Parhi - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Transdermal drug delivery (TDD) was initially limited to fewer therapeutic agents due to the
requirements of suitable physicochemical and biological properties for passage across the …