Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …

Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …

Previous work has shown that mature B cells depend upon survival signals delivered to the
cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal …

The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …

The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …

Abstracts Early B cell lymphopoiesis depends on E2A, Ebf1, Pax5 and Ikaros family
members. In the present study, we used acute protein degradation in mice to identify direct …

Abstract The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal
with diagnosis matters using morphology and immunophenotyping. This group aimed at …