The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Neuroendocrine role for VGF

JE Lewis, JM Brameld, PH Jethwa - Frontiers in endocrinology, 2015 - frontiersin.org
The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its
rapid induction in vitro by nerve growth factor, although can also be induced by brain …

Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells

S Hannedouche, V Beck, J Leighton-Davies… - Journal of Biological …, 2013 - ASBMB
TLQP-21, a peptide derived from VGF (non-acronymic) by proteolytic processing, has been
shown to modulate energy metabolism, differentiation, and cellular response to stress …

Sleeve gastrectomy reveals the plasticity of the human gastric epithelium

A Elad, B Moalem, D Sender, A Bardugo… - Nature …, 2025 - nature.com
Gastrin is secreted following a rise in gastric pH, leading to gastric acid secretion. Sleeve
gastrectomy (SG), a bariatric surgery where 80% of the gastric corpus is excised, presents a …

VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers

GL Ferri, B Noli, C Brancia, F D'Amato… - Journal of chemical …, 2011 - Elsevier
The vgf gene (non-acronymic) is induced in vivo by neurotrophins including Nerve Growth
Factor (NGF), Brain Derived Growth Factor (BDNF) and Glial Derived Growth Factor (GDNF) …

Role of hypothalamic VGF in energy balance and metabolic adaption to environmental enrichment in mice

GD Foglesong, W Huang, X Liu, AM Slater, J Siu… - …, 2016 - academic.oup.com
Environmental enrichment (EE), a housing condition providing complex physical, social, and
cognitive stimulation, leads to improved metabolic health and resistance to diet-induced …

VGF peptide profiles in type 2 diabetic patients' plasma and in obese mice

F D'Amato, B Noli, L Angioni, E Cossu, M Incani… - PLoS …, 2015 - journals.plos.org
To address the possible involvement of VGF peptides in obesity and diabetes, we studied
type 2 diabetes (T2D) and obese patients, and high-fat diet induced obese mice. Two VGF …

VGF protein and Its C-terminal derived peptides in amyotrophic lateral sclerosis: human and animal model studies

C Brancia, B Noli, M Boido, A Boi, R Puddu… - PloS one, 2016 - journals.plos.org
VGF mRNA is widely expressed in areas of the nervous system known to degenerate in
Amyotrophic Lateral Sclerosis (ALS), including cerebral cortex, brainstem and spinal cord …

Profiles of VGF peptides in the rat brain and their modulations after phencyclidine treatment

B Noli, F Sanna, C Brancia, F D'Amato… - Frontiers in cellular …, 2017 - frontiersin.org
From the VGF precursor protein originate several low molecular weight peptides, whose
distribution in the brain and blood circulation is not entirely known. Among the VGF peptides …

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties: focus on in vitro calcium signaling

E Bresciani, R Possenti, S Coco, L Rizzi… - International Journal of …, 2019 - mdpi.com
VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and
617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but …