Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth
factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly …

Acquired resistance has curtailed cancer survival since the dawn of the chemotherapy age
more than half a century ago. Although the application of stem cell (SC) concepts to cancer …

Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and
tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells …

Glioblastoma remains the most common and devastating primary brain tumor despite
maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) …

Emerging evidence has shown that GSK3β plays oncogenic roles in multiple tumour types;
however, the underlying mechanisms remain largely unknown. Here, we show that nuclear …