Prevalence and estimation of hepatitis B and C infections in the WHO European Region: a review of data focusing on the countries outside the European Union and …

VD Hope, I Eramova, D Capurro… - Epidemiology & …, 2014 - cambridge.org
Knowledge of hepatitis B and C prevalence, and numbers infected, are important for
planning responses. Published HBsAg and anti-HCV prevalences for the 20 WHO European …

Cell cycle regulation during viral infection

S Bagga, MJ Bouchard - Cell Cycle Control: Mechanisms and Protocols, 2014 - Springer
To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052

RA Fridell, D Qiu, L Valera, C Wang, RE Rose… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT BMS-790052, targeting nonstructural protein 5A (NS5A), is the most potent
hepatitis C virus (HCV) inhibitor described to date. It is highly effective against genotype 1 …

Prevalence of hepatitis C virus genotypes in Pakistan: current scenario and review of literature

A Haqqi, R Munir, M Khalid, M Khurram, M Zaid… - Viral …, 2019 - liebertpub.com
Hepatitis C virus (HCV) is a major public health concern globally, resulting in liver-related
complications. Approximately 6% population of Pakistan is infected with HCV. HCV is error …

Zika virus NS5 protein potential inhibitors: an enhanced in silico approach in drug discovery

P Ramharack, MES Soliman - Journal of Biomolecular Structure …, 2018 - Taylor & Francis
The re-emerging Zika virus (ZIKV) is an arthropod-borne virus that has been described to
have explosive potential as a worldwide pandemic. The initial transmission of the virus was …

PEGylation and its impact on the design of new protein-based medicines

C Ginn, H Khalili, R Lever… - Future Medicinal Chemistry, 2014 - Taylor & Francis
PEGylation is the covalent conjugation of PEG to therapeutic molecules. Protein PEGylation
is a clinically proven approach for extending the circulation half-life and reducing the …

(−)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus

C Chen, H Qiu, J Gong, Q Liu, H Xiao, XW Chen… - Archives of …, 2012 - Springer
Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. In this study,
we found that hepatitis C virus (HCV) infection was significantly suppressed by EGCG in an …

Emerging viral infections in Pakistan: issues, concerns, and future prospects

AT Khalil, M Ali, F Tanveer, M Ovais, M Idrees… - Health …, 2017 - liebertpub.com
Emerging infectious diseases pose a serious threat to public health security; this is
especially true in the underdeveloped world because of limited resources to combat them …

Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT

MH Chen, MY Lee, JJ Chuang… - International …, 2012 - spandidos-publications.com
Although hepatitis C virus (HCV) affects approximately 130-170 million people worldwide,
no vaccines are available. HCV is an important cause of chronic hepatitis, cirrhosis and …

Impact of HCV genotype on treatment regimens and drug resistance: a snapshot in time

L Cuypers, F Ceccherini‐Silberstein… - Reviews in Medical …, 2016 - Wiley Online Library
The introduction of highly potent direct‐acting antivirals (DAAs) has revolutionized hepatitis
C virus treatment. Nevertheless, viral eradication worldwide remains a challenge also in the …