HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000–2011: Rosetta Stone for NPC: genetics, viral …

A Hildesheim, CP Wang - Seminars in cancer biology, 2012 - Elsevier
While infection with Epstein–Barr virus (EBV) is known to be an essential risk factor for the
development of nasopharyngeal carcinoma (NPC), other co-factors including genetic factors …

[HTML][HTML] The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact

G Mountzios, T Rampias, A Psyrri - Annals of oncology, 2014 - Elsevier
Squamous-cell cancer of the head and neck (SCCHN) represents a heterogeneous disease
entity, with various etiological factors implicated in the genesis of distinct molecular subsets …

Human leukocyte antigen-G (HLA-G) expression in cancers: roles in immune evasion, metastasis and target for therapy

A Lin, WH Yan - Molecular Medicine, 2015 - Springer
Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in
various malignancies and is strongly associated with tumor immune escape, metastasis and …

Role of HLA-G in viral infections

S Jasinski-Bergner, D Schmiedel… - Frontiers in …, 2022 - frontiersin.org
The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has
distinct features to classical HLA-A,-B,-C antigens, such as a low polymorphism, different …

The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases

FC Dias, EC Castelli, CVA Collares, P Moreau… - Frontiers in …, 2015 - frontiersin.org
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic
properties, HLA-G expression is expected to be deleterious when present in tumor cells and …

[HTML][HTML] Human leukocyte antigen-G is frequently expressed in glioblastoma and may be induced in vitro by combined 5-aza-2′-deoxycytidine and interferon-γ …

IJ Wastowski, RT Simões, L Yaghi, EA Donadi… - The American journal of …, 2013 - Elsevier
Human leukocyte antigen-G (HLA-G) is a nonclassical major histocompatibility complex
(MHC) class I molecule involved in immune tolerance processes, playing an important role …

[HTML][HTML] The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma

ML Lung, AKL Cheung, JMY Ko, HL Lung… - Chinese journal of …, 2014 - ncbi.nlm.nih.gov
The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes
to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic …

Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment

Y Zhang, S Yu, Y Han, Y Wang… - Oncology letters, 2018 - spandidos-publications.com
Human leukocyte antigen‑G (HLA‑G) is a non‑classical HLA molecule, predominantly
expressed in cytotrophoblast cells to protect the fetus during pregnancy. Notably, a high …

[HTML][HTML] Human leucocyte antigen-G polymorphisms are associated with cervical squamous cell carcinoma risk in Taiwanese women

YC Yang, TY Chang, TC Chen, WS Lin… - European Journal of …, 2014 - Elsevier
Background The mere presence of human papillomavirus (HPV) is not enough for cervical
cancer development and immunogenetic background may play an important role. Human …