The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after …

Understanding distinct gene expression patterns of normal adult and developing fetal
human pancreatic α-and β-cells is crucial for developing stem cell therapies, islet …

Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are
therefore considered 'non-functional',–. As clinical behaviors vary widely and distant …

Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood
glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing …

Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

Islet non-β-cells, the α-δ-and pancreatic polypeptide cells (PP-cells), are important
components of islet architecture and intercellular communication. In α-cells, glucagon is …

Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing
α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it …

The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …