Malformations of cortical development and epilepsy

RJ Leventer, R Guerrini, WB Dobyns - Dialogues in clinical …, 2008 - Taylor & Francis
Malformations of cortical development (MCDs) are macroscopic or microscopic
abnormalities of the cerebral cortex that arise as a consequence of an interruption to the …

Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options

R Guerrini, WB Dobyns, AJ Barkovich - Trends in neurosciences, 2008 - cell.com
Genetic studies have identified several of the genes associated with malformations of
cortical development which might disrupt each of the main stages of cell proliferation and …

Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula

P Ryvlin, L Minotti, G Demarquay, E Hirsch… - …, 2006 - Wiley Online Library
Purpose: To report three patients with drug‐resistant nocturnal hypermotor seizures (NHSs),
no detectable brain lesion, and clinically defined nocturnal frontal lobe epilepsy (NFLE) or …

Clinical and imaging features of cortical malformations in childhood

RJ Leventer, EM Phelan, LT Coleman, MJ Kean… - Neurology, 1999 - AAN Enterprises
Objective: To determine the types, relative frequencies, clinical features, and MRI
characteristics of malformations of cortical development (MCD) occurring in a cohort of …

Surgery for malformations of cortical development causing epilepsy

SM Sisodiya - Brain, 2000 - academic.oup.com
Malformations of cortical development (MCD) are responsible for many cases of refractory
epilepsy in adults and children. The results of surgical treatment are difficult to assess from …

Occipital epilepsies: identification of specific and newly recognized syndromes

I Taylor, IE Scheffer, SF Berkovic - Brain, 2003 - academic.oup.com
Occipital epilepsies often elude diagnosis as they frequently masquerade as other seizure
syndromes. Visual hallucinations are the key clinical symptoms indicating an occipital focus …

Malformations of cortical development: burdens and insights from important causes of human epilepsy

SM Sisodiya - The Lancet Neurology, 2004 - thelancet.com
Malformations of cortical development (MCD) are important causes of chronic epilepsy in
human beings. A blanket term, MCD encompasses many varied developmental disorders …

Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes

L Tassi, N Colombo, M Cossu, R Mai, S Francione… - Brain, 2005 - academic.oup.com
We present the results of a retrospective study on 10 patients operated on for intractable
epilepsy associated with nodular heterotopia as identified by high resolution MRI. Seven …

Surgical outcome in patients with epilepsy and dual pathology

LM Li, F Cendes, F Andermann, C Watson, DR Fish… - Brain, 1999 - academic.oup.com
High-resolution MRI can detect dual pathology (an extrahippocampal lesion plus
hippocampal atrophy) in about 5–20% of patients with refractory partial epilepsy referred for …

The hidden causes of surgery-resistant temporal lobe epilepsy: extratemporal or temporal plus? editorial review

P Ryvlin, P Kahane - Current opinion in neurology, 2005 - journals.lww.com
Temporal lobe epilepsy (TLE) surgery has benefited from several important advances during
the past 2 decades, thanks to the development of neuroimaging and the identification of …