The role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes
Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society
L Zanoli, M Briet, JP Empana, PG Cunha… - Journal of …, 2020 - journals.lww.com
Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …
Aortic cellular diversity and quantitative genome-wide association study trait prioritization through single-nuclear RNA sequencing of the aneurysmal human aorta
EL Chou, M Chaffin, B Simonson… - … and Vascular Biology, 2022 - Am Heart Assoc
Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …
promote extracellular matrix destruction and structural weakening. To explore this biology …
Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension
MR Bersi, R Khosravi, AJ Wujciak… - Journal of The …, 2017 - royalsocietypublishing.org
The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …
MiR155-5p in adventitial fibroblasts-derived extracellular vesicles inhibits vascular smooth muscle cell proliferation via suppressing angiotensin-converting enzyme …
Proliferation of vascular smooth muscle cells (VSMCs) plays crucial roles in vascular
remodelling and stiffening in hypertension. Vascular adventitial fibroblasts are a key …
remodelling and stiffening in hypertension. Vascular adventitial fibroblasts are a key …
MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 …
JJ Song, M Yang, Y Liu, JW Song, J Wang… - European journal of …, 2020 - Elsevier
Abnormal aortic adventitial fibroblasts (AFs) play essential roles in the development of
vascular remodeling and disorders. Previous studies revealed that microRNA-122 (miR …
vascular remodeling and disorders. Previous studies revealed that microRNA-122 (miR …
Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta that can lead to life-
threatening dissection or rupture. In vivo assessments of TAA progression are largely limited …
threatening dissection or rupture. In vivo assessments of TAA progression are largely limited …
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress
NCA van Engeland, F Suarez Rodriguez… - Scientific reports, 2019 - nature.com
The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …
[HTML][HTML] Mechanisms of aortic dissection: from pathological changes to experimental and in silico models
Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …
recent advances in medical data assimilation and in experimental and in silico models have …
Kaempferol prevents against Ang II-induced cardiac remodeling through attenuating Ang II-induced inflammation and oxidative stress
Y Du, J Han, H Zhang, J Xu, L Jiang… - Journal of Cardiovascular …, 2019 - journals.lww.com
Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II)
induces cardiac inflammation and oxidative stress, which also is implicated in the …
induces cardiac inflammation and oxidative stress, which also is implicated in the …