In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and
progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

Clinical trials identified intravitreal vascular endothelial growth factor inhibitors (anti-VEGF
agents) have the potential to stabilise or even improve visual acuity outcomes in …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Introduction confirmed this result and further revealed that in the Blood vessels are
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …

We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we
have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma …

New growth in the vascular network is important since the proliferation, as well as metastatic
spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the …