Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization
AMPA glutamate receptors (AMPARs) are ion channel tetramers that mediate the majority of
fast excitatory synaptic transmission. They are composed of four subunits (GluA1–GluA4); …
fast excitatory synaptic transmission. They are composed of four subunits (GluA1–GluA4); …
Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP
T Fuchsberger, I Stockwell, M Woods, Z Brzosko… - bioRxiv, 2024 - biorxiv.org
The reward and novelty related neuromodulator dopamine plays an important role in
hippocampal long-term memory, which is thought to involve protein synthesis-dependent …
hippocampal long-term memory, which is thought to involve protein synthesis-dependent …
Research briefing
LPM Kremer - Nature Methods, 2024 - nature.com
Single-cell bisulfite sequencing enables the genome-wide quantification of DNA methylation
at single-cell resolution, but methods to analyze the resulting data are lacking. The …
at single-cell resolution, but methods to analyze the resulting data are lacking. The …
In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET
RG Held, J Liang, L Esquivies, YA Khan, C Wang… - bioRxiv, 2024 - biorxiv.org
Most synapses in the brain transmit information by the presynaptic release of vesicular
glutamate, driving postsynaptic depolarization through AMPA-type glutamate receptors …
glutamate, driving postsynaptic depolarization through AMPA-type glutamate receptors …
The VGCC auxiliary subunit α2δ1 is an extracellular GluA1 interactor and regulates LTP, spatial memory, and seizure susceptibility
G Leana-Sandoval, AV Kolli, MA Sandoval… - bioRxiv, 2024 - biorxiv.org
Activity-dependent synaptic accumulation of AMPA receptors (AMPARs) and subsequent
long-term synaptic strengthening underlie different forms of learning and memory. The …
long-term synaptic strengthening underlie different forms of learning and memory. The …